Debbie Goh Hui Jie

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Doctor Details

2024/01/25

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Dr Debbie Goh Hui Jie

Designations:

Associate Consultant, Department of Ophthalmology, National University Hospital

Qualifications:

MBBS (UCL), PhD, MMed (Ophth), FAMS, FRCOphth (UK)

Specialties/Sub-specialties:

Ophthalmology

Clinical Disciplines/Programmes:

Cataract, General Ophthalmology, Retina (Medical), Retina (Surgical)

Special Interests:

Age Related Macular Degeneration, Diabetic Eye Disease, Cataract, Retina Detachment

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Contact Us:

eye_surgery@nuhs.edu.sg

Find Out More:

www.nuh.com.sg/eye

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Biosketch

Dr Debbie Goh is an Associate Consultant in the Department of Ophthalmology at National University Hospital (NUH). She is a clinician-scientist with a clinical practice encompassing comprehensive ophthalmology and cataract surgery, with developing subspecialty expertise in medical retina and vitreoretinal disease.

Dr Goh earned her Bachelor of Science (Honours), Bachelor of Medicine and Surgery, and Doctor of Philosophy from University College London. She subsequently obtained her Masters of Medicine in Ophthalmology from the National University of Singapore in 2024, and holds fellowship from the Royal College of Ophthalmologists (UK) and the Academy of Medicine (Singapore). During her residency training, she served as Chief Resident from 2024 to 2025 and completed the 12th Singapore Chief Residency Programme.

Driven by a commitment to integrating clinical medicine with translational research, Dr Goh was awarded the A*STAR National Science Scholarship (MBBS-PhD), which supported her medical and doctoral training. Her PhD research focused on photoreceptor transplantation, and her subsequent research has spanned inherited retinal diseases, retinal degeneration, retinal pigment epithelial biology and stem cell-based therapies. Her current research interests include retinal regeneration and translational retinal science. She was Lead Principal Investigator of an NUHS Health Services Research Seed Grant investigating home-based retinal imaging for chronic retinal diseases, and has presented her clinical and research work at regional and international meetings.

Dr Goh is fluent in English and Mandarin.

Journals & Publications

Ali SM, Parikh BH, Tan QSW, Hübner B, Kozyrina AN, Banerjee A, Zhao J, Goh D, Bogireddi H, Yeo SW, Wong DSL, Xu J, Tran KC, Liu Z, Le Y, Barathi VA, Cheong KH, Russo JD, Ludwig A, Hunziker W, Su X. ZO-1/Tjp1 and ZO-2/Tjp2 deletion in retinal pigment epithelium causes progressive retinal degeneration. iScience. 2025 Oct; 28(11):113673.
Seah I, Goh D, Banerjee A, Su X. Modelling Inherited Retinal Diseases Using Human Induced Pluripotent Stem Cell Derived Photoreceptor Cells and Retinal Pigment Epithelial Cells. Front. Med. Sec. Ophthalmology. 2024; 11.
Seah I*, Goh D*, Chan HW, Su X. Developing Non-Human Primate Models of Inherited Retinal Diseases. Genes. 2022; 13(2):344.
Lingam S, Liu Z, Yang B, Wong W, Parikh BH, Ong JY, Goh D, Wong DSL, Tan QSW, Tan GSW, Holder GE, Regha K, Barathi V, Hunziker W, Lingam G, Zeng X, Su X. cGMP-grade human iPSC-derived retinal photoreceptor precursor cells rescue cone photoreceptor damage in non-human primates. Stem Cell Research & Therapy. 2021 Aug 19; 12 (464).
Ribeiro J, Procyk C, West EL, O’Hara-Wright M, Martins MF, Moshtagh-Khorasani M, Hare A, Basche M, Fernando M, Goh D, Jumbo N, Rizzi M, Powell K, Bainbridge JWB, Smith AJ, Pearson RA, Gonzalez-Cordero A, Ali RR. Restoration of visual function in advanced disease after transplantation of purified human pluripotent stem cell-derived cone photoreceptors. Cell Reports. 2021 Apr 20; 35(3):109022.
Gonzalez-Cordero A*, Goh D*, Kruczek K, Naeem A, Fernando M, Takaaki M, kleine Holthaus SM, Blackford SJI, Kloc M, Borooah S, Georgiadis A, Mehat M, Ho J, Chu C, Duran Y, Ovando-Roche P, Hippert C. West EL, Smith AJ, Pearson RA, Ali RR. Assessment of AAV vector tropisms for mouse and human pluripotent stem cell-derived RPE and photoreceptor cells. Human Gene Therapy. 2018 Oct;29(10):1124-1139.
Waldron PV, Di Marco F, Kruczek K, Ribeiro J, Graca AB, Hippert C, Aghaizu ND, Kalargyrou AA, Barber AC, Grimaldi G, Duran Y, Blackford SJI, Kloc M, Goh D, Aldunate EZ, Sampson RD, Bainbridge JWB, Smith AJ, Gonzalez-Cordero A, Sowden JC, Ali RR, Pearson RA. Transplanted donor- or stem cell-derived cone photoreceptors can both integrate and undergo material transfer in an environment-dependent manner. Stem Cell Reports. 2018 Jan 4. pii: S2213-6711(17)30556-8.
Gonzalez-Cordero A, Kruczek K, Naeem A, Fernando M, Kloc M, Ribeiro JC, Goh D, Duran Y, Blackford SJI, Abelleira-Hervas L, Sampson RD, Shum IO, Branch MJ, Gardner PJ, Sowden JC, Bainbridge JWB, Smith AJ, West EL, Pearson RA, Ali RR. Recapitulation of human retinal development from human pluripotent stem cells generates transplantable populations of cone photoreceptors. Stem Cell Reports. 2017 Sep 12;9(3):820-837.
Kruczek K, Gonzalez-Cordero A, Goh D, Naeem A, Jonikas M, Blackford SJI, Kloc M, Duran Y, Georgiadis A, Sampson RD, Maswood RN, Smith AJ, Decembrini S, Arsenijevic Y, Sowden JC, Pearson RA, West EL, Ali RR. Differentiation and transplantation of embryonic stem cell-derived cone photoreceptors into a mouse model of end-stage retinal degeneration. Stem Cell Reports. 2017 Jun 6;8(6):1659-1674.
Pearson RA, Gonzalez-Cordero A, West EL, Ribeiro JC, Aghaizu N, Goh D, Sampson R, Georgiadis A, Waldron P, Duran Y, Naeem A., Kloc M, Cristante E, Kruczek K, Sowden JC, Smith AJ, Ali RR. Donor and host photoreceptors engage in material transfer following transplantation of post-mitotic photoreceptor precursors. Nat Comms. 2016 Oct 4;7:13029.

Professional Memberships

College of Ophthalmologists, Academy of Medicine, Singapore
The Royal College of Ophthalmologists, United Kingdom

2026/08/24